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An association between the 5-HT2A receptor gene T102C polymorphism and Schizophrenia.

Dingqin, Jiang Kaida, Tang guomei, el al. Shanghai Mental Health Centre. Shanghai, 200030.  
Objective: To investigate the relation between the 5-HT2A receptor gene T102C polymorphism and schizophrenia in Chinese Han population. Method: 286 schizophrenic patients were recruited from Shanghai Mental Health Center, and were splited into chronic (duration 10 years) and non-chronic group (duration 5 years). Genomic DNA was extracted from peripheral lymphocytes according to standard procedures and was genotyped by polymerase chain reaction (PCR) methods and restriction fragment length polymorphism (RFLP) typing. Results: The frequencies of A2 allele and A2 / A2 genotype of 5-HT2A receptor gene polymorphism in nonchronic patients were significantly enhanced compared with normal controls (A2 allele: Z = 2.97, P0.05; A2/A2 genotype: Z = 2.19, P0.05), showing strong associations between A2 allele (OR = 2.35, P0.05), A2/A2 genotype (OR= 1.45, P0.05) and non-chronic Schizophrenia. But no significant difference in the distribution of the T102C polymorphism between chronic Schizophrenic cases and matched controls were detected. Conclusion: In Chinese Han population, the 5-HT2A receptor gene polymorphism might be associated with non-chronic Schizophrenia but not with chronic Schizophrenia.
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