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Effect of clozapine in different dosage on the lipid metabolism in patients with schizophrenia

Jiang Junsheng,Shou Taojun,Xu Peng.Dongyang mental hospital,Dongyang 322118  
Objective: To explore the effect of clozapine in different dosage on patients with schizophrenia.Methods: 78 male schizophrence were randomly divided into three groups:low dosage group(clozapine150mg/d),middle dosage group(clozapine150~300mg/d) and high dosage group(clozapine300mg/d).Blood fat,weight index were detected prior treatment and after 6 weeks.Results:Triglyceride(TG) level of three groups significantly heightened(P0.05 or P0.01) after treatment,especially that of low dosage group.High density lipoprotein level(HDL) decreased and low density lipoprotein(LDL) lever heightened(P0.05 and P0.01) in high dosage group after 6 weeks.Weight gain both in middle and high dosage groups has significantly difference after treatment.Weight gain has no obviously correlation with TG,HDL and LDL(P0.05).Conclusion:Clozapine could change the levels of blood fat.Weight increases with the dosage increasing of cloazpine.
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