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Quetiapine and chlorpromazine in the treatment of schizophrenia:a random,controlled trial

Cai Qingqi,Wang Zhewei,Lin Yichuan,Zhang Xiaoyang.The Third Hospital of Quanzhou,Fujian Provence,Quanzhou 362000  
Objective: To explore the efficacy and safety of quetiapine in the treatment of schizophrenia.Methods: A total of 94 patients with schizophrenia(CCMD-3 criteria) were randomly allocated to quetiapine(n=48) and chlorpromazine(n=46) group.All patients were treated for 8 weeks.Efficacy in schizophrenia was determined using the PANSS scale.Safety was evaluated using TESS scale.Results:PANSS scale in endpoint was decreased significantly than baseline in both groups(P0.01).Excellence and remission rate in quetiapine group was 70.8% and 87.5% respectively,chlorpromazine group 67.4% and 84.8% respectively.No significant difference exist within treatment groups.Quetiapine treated patients demonstrated significantly decrease in PANSS negative factor,cognitive factor,PANSS total scale than chlorpromazine-treated patients(P0.01).The adverse effect in chlorpromazine-treated patients was significantly more and greater than quetiapine-treated patients(P0.05).Conclusion:No significant difference between quetiapine and chlorpromazine groups was observed for efficacy.Quetiapine,which has less adverse effect,more ability to improve the cognitive function and negative symptom than chlorpromazine,is an effective and safe antipsychotic drug.
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