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Efficacy of mirtazapine and paraxetine in treatment of panic disorder

Liu Wei,LiuYing.The Thirth People's Hospital of Heze,Shandong 274031  
Objective: To investingate the clinical and side effects of mirtazapine io treating the patients with panic disorder.Methods: A total of 42 patients with panic disorder wer divided into two groups randomly.The patients of study group were treated with mirtazapine and paroxetine was given to the control group.All the subjects were rated by Hamiton Anxiety Scale(HAMA) and Rating Scale for Side Effects(SERS) at the baseline and at the end of week one,two,four,six,eight,respectively.Results:Score of HAMA in the study group was significantly higher than zhat in the control group at the end of the first two weeks,but there were no significant differences between the two groups in both clinical effect and side effects at the end of week 4,6,8.The remission and response rates were 65% and 90% respectively in the study group at the end of eighth week according to the score change of HAMA.Those rates were 63.6% and 90.9% respectively in paroxetine group.Conclusion:The clinical and side effects of mirtazapine in treating the patients with panic disorder are similar to those of paroxetine.
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