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《Military Medical Sciences》 2011-05
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Effects of AduoLa Fuzhenglin on changes of cytochrome c oxidase in rats′hippocampus after microwave exposure

XIONG Lu,PENG Rui-yun,GAO Ya-bing,WANG Shui-ming,WANG Li-feng,DONG Ji,ZHAO Li,LI Yang,ZUO Hong-yan,XU Xin-ping,WANG Xiao-min,LIU Shu-chen(Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China)  
Objective To investigate the effect of a herb compound AduoLa Fuzhenglin(ADL) on the gene cytochrome c oxidase(COX) change of the mitochondrial respiratory chain in rats′ hippocampus after microwave exposure.Methods One hundred Wistar male rats were exposed to microwave at the average power density of 30 mW/cm2for 15 min,3 g/(kg·d) ADL was administrated for 14 days before or after radiation.Rats were sacrificed at 6 h and 14 d after exposure.The activity of COX was determined by colorimetry;real time polymerase chain reaction was used to study the expression of COX Ⅰ and Ⅳ mRNA;the COX Ⅰ protein was detected by Western blot and image analysis.Results The level of COX activity,COX Ⅰ and Ⅳ mRNA and COX protein was decreased obviously in the radiated control group(P0.05 or P0.01) at 6 h and in the prophylaxis and treatment groups after drug withdrawal.The activity and gene expression of COX in the ADL prophylaxis group were higher than those in the radiated control group,and were not significant different from the normal control.Compared with the radiated control group,those in the ADL treatment group were significantly increased(P0.05),and almost returned to normal.Conclusion Administration of 3 g/(kg·d) ADL could lessen the decrease in the COX expression level of the mitochondrial respiratory chain in rats′ hippocampus after microwave exposure,and with better effect on ADL treatment group.
【Fund】: 国家科技重大专项(2008ZXJ09004-019)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Qiang, CAO Zhao-jin, BAI Xue-tao. Institute for Environmental Health and Related Product Safety, China Center for Disease Control and Prevention, Beijing 100021, China;Effect of Microwave Electromagnetic Fields on Activity of Energy Metabolism Cytochrome Oxidase in Cerebral Cortical Neurons of Postnatal Rats[J];Journal of Environment and Health;2005-05
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 XIA Hongjie~(1,2) WANG Dewen~2 1 (Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China) 2 (Department of Integrated Traditional Chinese Medicine and Western Medicine for Rehabilitation,General Hospital of Chinese Peoples Armed Police Force,Beijing 100039,China);Effects of electromagnetic radiation on organism[J];Journal of Radiation Research and Radiation Processing;2008-05
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1 Cao Zhaojin, Zhao Xiaolin, Tao Yong, Wan Chao, et al. Institute of Environmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing 100021,China;Effects of electromagnetic radiation from cellular telephone handsets on symptoms of neurasthenia[J];JOURNAL OF HYGIENE RESEARCH;2000-06
2 Bai Xuetao Institute of Environmental Health Monitoring, Chinese Academy of Preventive Medicine, Beijing 100021, China;Method of separate culture of primary neurons using glial feeder layer[J];Journal of Hygiene Research;2002-04
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