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《MYCOSYSTEMA》 1999-01
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EFFECT OF SACCHAROMYCES CEREVISIAE BD101 Cu-MT ON RESISTING IRRADIATION DAMAGE IN YEAST AND MICE

JIA Le; WANG Long; LIN Zhilan; XUE Hongwei; WEI Xuetao; LIN Weici (College of Life Sciences, Peking University, Beijing 100871)(College Of Public Health, Beijing Medical University, Beijing 100083)  
The Cu-metallothionein of Saccharomyces cerevisiae BD101 can scavenge hydroxyl radicals. The yeast cells containing Cu-MT can protect against 60Coγray irradiation damage. The effects of S. cerevisiae BD101 Cu-MT on resisting irradiation damage in 60Coγ ray irradiation mice were studied by counting the changes of platelet (PLT) and white blood corpuscle (WBC). It was demonstrated that the BD101 Cu-MT could reduce the decrease in the number of PLT and promote it to rise back, but it has not been observed that this Cu-metallothionein could affect positively the change of the number of WBC. It suggests that there is a promising prospect for applying S.cerevisiae BD101 Cu-metallotionein to clinical irradiation sickness and to resistance of shedding blood after irradiation therapy.
【Fund】: 国家自然科学基金!39370021
【CateGory Index】: Q939.93
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