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《Mycosystema》 2018-01
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Isolation of secondary metabolites with acetylcholinesterase inhibitory activity of endophytic fungus Pezicula sp. JR14 from Huperzia serrata

ZHENG Rui;ZHANG Zhi-Bin;YAN Ri-Ming;WANG Ya;XIAO Yi-Wen;ZHU Du;Key Laboratory of Protection and Utilization of Subtropic Plant Resources of Jiangxi Province,Jiangxi Normal University;Key Lab of Bioprocess Engineering of Jiangxi Province,College of Life Sciences,Jiangxi Science and Technology Normal University;  
An endophytic fungus strain JR14 with acetylcholinesterase(ACh E)inhibitory activity from Huperzia serrata was identified as Pezicula sp.by morphological characteristics and internal transcribed spacer(ITS)sequence analysis.Four kinds of secondary metabolites were separated and purified from the ethyl acetate extract of the endophytic Pezicula sp.JR14.According to mass spectrometry,~1H-NMR and ~(13)C-NMR analyses,they were identified as behenic acid(1),himeic acid B(2),secalonic acid A(3)and palmitic acid(4).Ellman colorimetric test proved that himeic acid B(2)showed better ACh E inhibitory activity with IC50 value of 205μg/mL(0.64mmol/L).
【Fund】: 国家自然科学基金(81760649 31760160);; 江西省自然科学基金(20171BAB204009);; 江西省教育厅科技项目(GJJ161624)~~
【CateGory Index】: Q936
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