Candida albicans morphological plasticity and pathogenesis
SUN Qiang-Qiang;LU Yang;College of Life Sciences, Wuhan University;
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most prevalent fungal pathogen of humans. It can cause superficial infections of the oropharynx, vagina, skin, and nails. In susceptible patients, C. albicans can enter the bloodstream and cause a frequently fatal disseminated infection. Morphological plasticity is its defining feature and is critical for its pathogenesis. A cell-type transition between yeast and hyphal morphologies in C. albicans was thought to underlie much of the variation in virulence observed in different host tissues. In addition, opaque, gray and gastrointestinally induced transition(GUT) cell types were recently reported that exhibit marked differences in vitro and in animal models of commensalism and disease. In this review, we explore the characteristics of these cell types of C. albicans. We highlight emerging knowledge about the associations of these different morphotypes with different host niches and virulence potential, as well as the environmental cues and signalling pathways that are involved in the morphological transitions.
【CateGory Index】： R379.4