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《Mycosystema》 2018-10
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The cell wall of Aspergillus fumigatus:composition,biosynthesis and function

FANG Wen-Xia;JIN Cheng;National Engineering Research Centre for Non-Food Biorefinery, Guangxi Academy of Sciences;State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences;  
Aspergillus fumigatus is a ubiquitous saprotrophic filamentous fungus in the environment. It is also the most common and life-threatening serial fungal pathogen, causing a variety of acute or chronic diseases in immunocompromised or immunodeficiency patients, including invasive aspergillosis that with high mortality rate. As a unique extracellular matrix fungal cell wall plays major roles in maintaining cell shape, protecting cells against the external stress, establishing polarized growth, invading new ecological niche and stimulating host immune response. Cell wall components are the biomarkers for the diagnosis of fungal infections, thus cell wall has been considered as the ideal target for the development of antifungal drugs. In recent decades, genetic, biochemical and immunological studies on the cell wall of A. fumigatus have made it an ideal model for studying the fungal cell wall. This review outlines composition, biosynthesis and function of A. fumigatus cell wall, and future research directions are proposed.
【Fund】: 广西壮族自治区第四批八桂学者建设工程专项经费;; 广西科学院科研启动费(2017YJJ025);; 广西自然科学基金(2018GXNSFAA138012)~~
【CateGory Index】: R379
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