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《Mycosystema》 2018-10
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Advances in the role and mechanism of plasmacytoid dendritic cells in the protection of cryptococcal pneumococcal infection

ZHANG Ke-Ming;ZHANG Lei;CAI Liang-Qi;LIU Xiao-Gang;PAN Wei-Hua;LIAO Wan-Qing;Shanghai Key Laboratory of Molecular Mycology, Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, and Dermatological Department, Changzheng Hospital;The First Affiliated Hospital of Xiamen University;  
Cryptococcus pneumonia is a common fungal disease which is caused by cryptococcal infection. Due to the nonspecific symptoms, it is difficult to make a definite diagnosis. As a conditional pathogenic fungal infection, the outcome of cryptococcal pneumonia is mainly related to host immunity. At present, the immunological pathogenesis of cryptococcal pneumonia is mainly limited to T cells and macrophages. In recent years, studies have shown that plasmacytoid dendritic cells, one of the subpopulations of dendritic cells, play a role in the human's resistance to virus and bacterial immunity because they can produce large amounts of type I interferons and activate related T cells. However, the role of plasmacytoid dendritic cells in fungal diseases, especially in cryptococcosis, remains unclear. This article will introduce the clinical manifestations, diagnosis and treatment of Cryptococcus pneumonia, and the immune mechanisms of T cells and macrophages in Cryptococcus pneumonia and introduce the previously reported links between cryptococcal pneumonia and plasmacytoid dendritic cells in order to initially explain the role of plasmacytoid dendritic cells in the pathogenesis of cryptococcal pneumonia immunology.
【Fund】: 国家自然科学基金(31770161);; 上海市科学技术委员会基金(14DZ2272900);; 国家卫生部基金(2018ZX10101003);; 上海市科委技术标准专项(16DZ0500401)~~
【CateGory Index】: R519
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