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《Mycosystema》 2018-10
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Effects of stress responses on pathogenicity of Aspergillus fumigatus:a review

WEI Yun-Yun;HE Dan;WANG Li;Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University;  
Aspergillus fumigatus is a widespread saprophytic fungus in the environment, and it is an important opportunistic pathogen. In recent years, with numbers of immunocompromised patients, invasive aspergillosis caused by A. fumigates is increasing, which has highest morbidity in systemic filamentous fungal infections. Due to the differences between natural environment and host microenvironment, on the premise of the conidia adapting to the microenvironment that A. fumigates can survive inside the host and cause infection. It was found that the microenvironmental adaptation of A. fumigates, such as thermotolerance, oxidative stress, osmotic stress, hypoxia, nutrient limitation, is probable related to its virulence. This paper reviews the relationship between stress responses and pathogenicity of A. fumigatus. It will contribute to analyze the pathogenesis of A. fumigatus and the findings will have great significance for the early diagnosis and treatment of invasive aspergillosis.
【Fund】: 国家自然科学基金(81271802)~~
【CateGory Index】: R379
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