The copper and iron homeostasis as important determinants during Cryptococcus infection
LI Yan-Jian;GAO Xin-Di;MENG Yang;DING Chen;College of Life and Health Sciences, Northeast University;
Metals are essential elements for many important biological processes in fungi and mammals. Numerous studies have extensively demonstrated the correlation between metal homeostasis and host-pathogen interaction. Metals, particularly copper and iron, participate in the modulation of fungal pathogenicity during systemic infection in the host. The host cells utilize copper and iron to battle fungal invasion. In this review, we elucidate fungal and mammalian homeostasis of copper and iron, and focus on the host-pathogen axis of cryptococcosis.
【CateGory Index】： R392