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《Mycosystema》 2018-10
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Research advances of secreted proteins in mediating the interaction between host and the fungal pathogen Candida albicans

WANG Yuan-Yuan;CHEN Chang-Bin;CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences;University of Chinese Academy of Sciences;  
Candida albicans is one of the most common opportunistic human fungal pathogens and mainly colonizes on the surface of human mucosa. It has been appreciated that secreted proteins of C. albicans play vital roles in mediating the interactions of this fungus with the host. Understanding the functions and action modes of secreted proteins will greatly benefit the study of pathogenesis of C. albicans and provides novel strategies for diagnosis, prevention and treatment of fungal infections. In this review, we describe the latest progresses in studying the secreted proteins in C. albicans and summarize their functions in tissue invasion, nutrient acquisition, cell wall maintenance and immune evasion when the fungus meets with the host. A few major directions that may gain more insights into this area is proposed.
【Fund】: 国家自然科学基金(31570140)~~
【CateGory Index】: R379.4
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