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《Fine Chemicals》 2017-08
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Synthesis and Anti-cancer Activity of Methacrylic Acid/Butyl Acrylate Grafted onto Bagasse Xylan Gallate

QIAN Jing-xia;LI He-ping;ZUO Kai;SUN Yan;ZOU Ying-dong;College of Chemistry and Bioengineering,Guilin University of Technology;  
Bagasse xylan gallate(Ⅰ) was synthesized by using bagasse xylan(BX) as main raw materials,gallic acid as esterifying agent,triethylamine as activation catalyst and N,N-dimethyl formamide(DMF) as the solvent. Subsequently,the graft copolymerization of methacrylic acid(MAA)/butyl acrylate(BA) onto bagasse xylan gallate was carried out by using ammonium persulfate as initiator. The parameters affecting the degree of substitution(DS),grafting rate(G),and grafting efficiency(GE) were investigated. The structure and properties of the product were characterized by FTIR,SEM,XRD and TG-DTG techniques. The results showed that the degree of substitution of productⅠwas 0. 64 under the conditions of n(BX) ∶n(trisacetyl-galloylchloride) = 1∶1,m(DMF) ∶m(BX) =9. 5∶1. 0,at 45 ℃ for 4. 0 h. The grafting rate and grafting efficiency of grafting copolymer(Ⅱ) was 23% and 67% when n(Ⅰ) ∶ n(BA) ∶ n(MAA) was 1∶1∶1,dosage of ammonium persulfate was 7%,at 50 ℃ for 8. 0 h. The anti-cancer activity of sample Ⅱ against some tumor cell lines was evaluated by using Methylthiazolyldiphenyl-tetrazolium bromide(MTT) method. The results showed that the inhibition rate on cancer cells of the liver reached to 28. 83%.
【Fund】: 国家自然科学基金项目(21676062)~~
【CateGory Index】: O636.1
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