Study on the Preparation of α- Isopropyl- p -chlorophenylacetyl Chloride
Din Enhai (The Third People's Police School of Beijing, Beijing 102600)Shen Deyuan (The Centre Laboratory of Nanjing Forestry University, Nanjing 210037)Jiang Peihua(Department of Chemical Engineering, Jiangsu Institute of Petrochemical Technology, Changzhou 213016)
Several processes for the manufacture of α- isopropyl- p -chlorophenylacetyl chloride in our country are introduced. A new process that α- isopropyl- p -chlorophenylacetyl chloride is preparated with α- isopropyl- p -chlorophenylacetic acid and chlorine as the raw materials in the presence of a small amount of sulfur and catalyst is presented. The effects of temperature, time, and catalyst on the preparation are discussed. The quality of the product is analyzed. The advantages and disadvantages of the new process are given, α- Cyano-phenoxybenzyl-2-(4-chlorophenyl)-3-methyl-butyrate is synthesized from said product, NaCN, and m- phenoxybenzaldehyde in the presence of solvent.