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《科学通报(英文版)》 2003-01
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Interaction between en- dogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension

SHI Yun, DU Junbao, GUO Zhiliang, ZENG Chaomei & TANG Chaoshu Department of Pediatrics, the First Hospital, Peking University, Beijing 100034, China Correspondence should be addressed to Du Junbao (e-mail: junbaodu@ ht.rol.cn)  
The aim of the study was to investigate the in-teraction between nitric oxygenase (NOS)/ nitric oxide (NO) and heme oxygenase (HO)/ carbon monoxide (CO) system in the pathogenesis of hypoxic pulmonary hypertension. On a rat model of hypoxic pulmonary hypertension, the pulmo-nary artery pressure was measured, and NO formation and expression of NOS in pulmonary tissues were examined after treatment with ZnPP-IX, an HO-1 inhibitor. The pulmonary artery pressure, CO formation and expression of HO-1 in pulmonary tissues were examined after treatment with L-NAME, a NOS inhibitor. We found that pulmonary hy-pertension developed after 2-week hypoxia, while the con-centration of NO in the pulmonary tissue homogenates and the expression of NOS in intrapulmonary artery endothelial cells decreased markedly. ZnPP-IX worsened pulmonary hypertension of hypoxic rats. However, it increased endoge-nous production of NO and the expression of NOS obviously. The concentration of CO in the pulmonary tissue homoge-nates and the expression of HO-1 in intrapulmonary artery smooth muscle cells increased markedly with hypoxic pul-monary hypertension. L-NAME worsened pulmonary hy-pertension of hypoxic rats, but inhibited CO formation and HO-1 expression (P 0.01). The results of this study sug-gested that endogenous NOS/NO and HO/CO systems might interact with each other and therefore play an important regulating role in hypoxic pulmonary hypertension.
【Fund】: This work was supported by the National Natural Science Foundation of China (Grant Nos. 30070796;; 30271373 and 39870844);; and the State Key Basic Research Program of China (Grant No. 200056905).
【CateGory Index】: R543.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 HE Chunping,TIAN De'an,WANG Bo,LIU Mei,DAN Zili,LUO Min,MEI Fan,XU Hubo, LIANG KuohuanDepartment of Digestive Disease,Tongji Hospital,Tongji Medical College,Huazhong Science and Technology University,Wuhan 430030,China;Impacts of hydrogen sulfide donor on experimental portal hypertension and endogenous nitric oxide/ nitric oxide synthase pathway[J];Chinese Journal of Gastroenterology and Hepatology;2007-06
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 ZHANG Qing you 1, DU Jun bao 1, SHI Lin 1,ZHANG Chun yu 1, YAN Hui 1, TANG Chao shu 2 (1.Department of Pediatrics, 2.Institute of Cardiovascular Research,Peking University First Hospital, Beijing 100034, China);Interaction between endogenous nitric oxide and hydrogen sulfide in pathogenesis of hypoxic pulmonary hypertension[J];Journal of Peking University(Health Sciences);2004-01
2 GENG Bin 1 , YAN Hui 2, ZHONG Guang zhen 3, ZHANG Chun yu 2, CHEN Xiao bo 2, JIANG Hong feng 1, TANG Chao shu 1 , DU Jun bao 2△ (1. Department of Physiology, Peking University School of Basic Medical Sciences ; 2. Department of Pediatrics, Peking University First Hospital, Beijing 100034, China; 3. Department of Cardiology, Peking University Third Hospital);Hydrogen sulfide: a novel cardiovascular functional regulatory gas factor[J];Journal of Peking University(Health Sciences);2004-01
3 SHI Lin, DU Jun bao, QI Jian guang, WEI Bing, et al. (The Department of Pediatrics, 1 Institute of Cardiovascular Research, The First Hospital of Peking University, Beijing 100034, China);Effects of L-arginine on pathologic structure and endogenous hydrogen sulfide pathway in rats with pulmonary hypertension induced by high pulmonary blood flow[J];Basic Medical Sciences and Clinics;2004-02
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Chinese Journal Full-text Database 1 Hits
1 Li-Xiu Song,Yong Zheng Department of Gastroenterology,the First Affi liated Hospital,College of Medicine,Shihezi University,Shihezi 832000,Xinjiang Uygur Autonomous Region,China;Role of gaseous signal molecules in the development of hepatic cirrhosis with portal hypertension[J];World Chinese Journal of Digestology;2009-19
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