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《科学通报(英文版)》 2003-05
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Study of-amyloid adsorption and aggregation on graphite by STM and AFM

WANG Zhigang, WAN Lijun, ZHOU Chunqing, FANG Xiaohong, WANG Chen & BAI Chunli Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Bai Chunli (e-mail: clbai@ infoc3.icas.ac.cn)  
The scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of -amyloid(1-42)(A42) on the hydrophobic graphite surface. It was found that A42 were preferentially adsorbed on graphite defects such as the edges. A42 peptides self-assembled into intermediate protofibrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation proc-ess of -amyloid.
【Fund】: theNationalNaturalScienceFoundation ofChina(GrantNos.20073053 and20121301)and theFoundation of theChineseAcademy ofSciences
【CateGory Index】: O647.3
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【References】
Chinese Journal Full-text Database 1 Hits
1 HE XiaoXiao, JIN Rong, YANG Liu, WANG KeMin, LI Wei, TAN WeiHong & LI HuiMin State Key Laboratory of Chemo/Biosensing and Chemometrics, Institute of Life Science and Biological Technology, Engineering Center for Biomedicine, College of Material Science and Technology, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, China;Study on the specific interaction between angiogenin and aptamer by atomic force microscopy (AFM)[J];科学通报(英文版);2008-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 SHI Hui, HE XiaoXiao, YANG XiaoHai, WANG KeMin, WANG Qing, GUO QiuPing & HUO XiQin State Key Laboratory of Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering, Biomedical Engineering Center, Hunan University; Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, China;Protein analysis based on molecular beacon probes and biofunctionalized nanoparticles[J];中国科学:化学(英文版);2010-04
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