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《科学通报(英文版)》 2003-17
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Effects of hyaluronic acid-chitosan-gelatin complex on the apoptosis and cell cycle of L929 cells

MAO Jinshu, WANG Xianghui, CUI Yuanlu & YAO Kangde Research Institute of Polymeric Materials, Tianjin University, Tianjin300072, China  
With the development in the field of tissue en-gineering, the interaction between biomaterials and cells has been deeply studied. Viewing the cells seeded on the surface of materials as an organic whole, cell cycle and apoptosis are analyzed to deepen the study of cell compatibility on bioma-terials, while cell proliferation and differentiation are stud-ied at the same time. In this paper, hyaluronic acid is incor-porated into the chitosan-gelatin system. Propidium iodide(PI) was used in cell cycle analysis and the double-staining of cells with annexin-V and PI was applied in cell apoptosisanalysis. The results show that incorporated hyaluronic acid shortens the adaptation period of cells on the material sur-face, and then cells enter the normal cell cycle quickly. Inaddition, added hyaluronic acid inhibits cell apoptosis trig-gered by the membranes. Therefore, hyaluronic acid im-proves the cell compatibility of chitosan-gelatin system andbenefits the design of biomimetic materials.
【CateGory Index】: Q26
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