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《Acta Academiae Medicinae Jiangxi》 2001-01
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Protective Effect of Tetrandrine on Mice Poisoned with Trichlorfon

LIU Han-qing,XIE Feng-xiang,LIANG Shang-dong, MU Song-niu,XU Bao-hua,GAO Yun (Department of Physiology, Jiangxi Medical College, Nanchang 330006,China; Faculty of Laboratory Animal Sciences, Jiangxi Medical College, Nanchang 330006,China)  
Acute toxicity experiment was done to determine the protective effect of tetrandrine on mice poisoned with trichlorfon (dipterex) of LD100.Significance in deviation of mortality between the poisoned mice treated with or without tetrandrine was examined by chisquare ( χ2 ) test.Results: Tetrandrine (20~40 mg/kg,i.p.) exhibited a definite protective effect on poisoned mice for the mortality of the animals treated with tetrandrine was significantly lower than that of the control group with normal saline ( P <0.05).The mortality in the group treated with tetrandrine was close to that in the group treated with atropine (10 mg/kg,i.p.) and there was no significant difference between them ( P >0.05).Conclusion: The results suggest that tetrandrine has protection against organophosphorus esters toxicity similar to that of atropine,and that it may be used as a synergist for atropine in the treatment of poisoning by these toxic compounds.The mechanism of action for tetrandrine is obscure at present and needs to be studied further.
【Fund】: 国家自然科学基金资助项目!(编号:39760082)
【CateGory Index】: R595.4
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【References】
Chinese Journal Full-text Database 1 Hits
1 XIONG Yu qing, FU Jun, LIU Han qing, LI Yan yan (Institute of Clinical Pharmacology, Jiangxi Medical College, Nanchang Jiangxi 330006, China);Influence of tetrandrine on activity of cholinesterase inhibited by organophosphate[J];Chinese Traditional and Herbal Drugs;2002-03
【Citations】
Chinese Journal Full-text Database 2 Hits
1 YF Hou~(**) and GQ Liu (Department of Pharmacology, China Pharmaceutical University, Nanjing)1988graduate student;THE EFFECTS OF TETRANDRINE, BERBAMINE AND SOME OTHER TETRAHYDROISOQUINOLINES ON [~3H] QNB BINDING TO M-CHOLINERGIC RECEPTORS IN RAT BRAIN[J];Acta Pharmaceutica Sinica;1988-11
2 Si Fu- zhong; Wang De-xin;Yang Guang-quan. Tengzhou People's Central Hospital,Shandong, 277500;ATROPINE DEPENDENCE DURING TREATMENT OF ACUTE ORGANOPHOSPHORUS PESTICIDES POISONING[J];CHINESE JOURNAL OF INTERNAL MEDICINE;1994-08
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Han Weitian, Chen Wenxiu, Shun Xiaoling Liaoning institute of Planned Parenthood Research, Shenyang;STUDY ON THE MUTAGENIC EFFECTS OF α-MOMORCHARIN[J];Carcinogenesis,Teratogenesis and Mutagenesis;1990-02
2 Zhan Guoying;Sun Jianqin;Sun Xiaohong;Wang HuiquN;Zhan Jian(Department of Nutrition and Food Hygiene,Gui Yang medical College.Gui Yang 550001);THE TOXICITY AND MUTAGENICITY TESTS OF VALERIANA[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1996-03
3 HUANG Xiao-bo et al(College of Forestry and Biotechnology,Zhejiang Forestry University,Lin'an,Zhejiang 311300);Medicinal Value and Resources Protection of Fungus Shiraia bambusicola[J];Journal of Anhui Agricultural Sciences;2009-28
4 WANG Chang-mei et al(School of Life Science,Yunnan Normal University,Kunming,Yunnan 650092);Toxicity Study on Phytohemagglutinin from White kidney Bean[J];Journal of Anhui Agricultural Sciences;2009-28
5 LIN Qi-cun et al (Hangzhou Academy of Agricultural Sciences,Hangzhou,Zhejiang 310024);Acute Toxicity Test of 6 Kinds of Common Drug on Hybrid Snakehead[J];Journal of Anhui Agricultural Sciences;2010-09
6 Wu Demin;Lei Yuanging;Yu Changmu(Institute of Prevention of Labour and Healthcare Professinal Diseases of Si Chuan Province,Chengdu 610041);Study Toxicity of a Color─Changing Toothcovering Material EB─4[J];BEIJING BIOMEDICAL ENGINEERING;1995-04
7 Cao Cheng-jing;Toxicological Study of Four Phenol Antioxides[J];;1982-02
8 Huo Guanhua,et al (Department of Histology and Embyology,Binzhou Medical College);TOXICITY AND TERATOLOGICAL EFFECTS OF SODIUM GLUTAMATE ON RATS[J];Journal of Binzhou Medical College;1993-02
9 Gao Yong,et al(The Laboratory of Toxicity,Binzhou Medical College);THE TOXICITY STUDY OF O-TOLUIDINE[J];JOURNAL OF BINZHOU MEDICAL COLLEGE;1995-05
10 Yin Muquan, et alDepartment of Army Hygiene;STUDIES ON THE TERATOGENIC EFFECT OF HYDROXYPIPERAQUINE PHOSPHATE[J];Academic Journal of Second Military Medical University;1981-04
China Proceedings of conference Full-text Database 2 Hits
1 ;The medicinal Plant Resources of Valerianaceae Possessing Sedative Action[A];[C];1998
2 LIN Qi-cun1,2,CHEN WUl,ZHOU Li-wei1,WANG Yu-xi1,FENG Xiao-yu1 (1.Hangzhou Academy of Agricultural Science,Hangzhou 310024,China; 2.Faculty of Life Science and Technology;Ningbo University;Ningbo 315211;China);Acute toxicity of six common aquacultural drugs to hybrid snakehead[A];[C];2010
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Yong-gang, CHI Yan-bang, YANG Tong-han (Department of General Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042,China);Changes of calcium content of hepatocytic mitochondria and protective effects of tetrandrine after biliary obstruction in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-04
2 Xiong Yili; Zhang Min; Yao Weixing(Department of Pharmacology,Xiaogan Medical School Department of OPharmacology,Tongji Medical University China);EFFECTS OF TETRANDRINE ON PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS AND EXPRESSION OF ONCOGENES[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;1998-02
3 Sun Donghong et al (Dept. of Occupational Health, Shanghai Medical Univ., 138, Yixueyuan Rd.,Shanghai, 200032, China);FURTHER STUDYON THE METHODOLOGY OF MEASUREMENT OF CHOLINESTERASES ACTIVITY IN BLOODI.STUDIES ON THE PROPORTION OF e-ChE/bl-ChE AND ADJUSTING THE RESULT WITH RBC COUNTING[J];INDUSTRIAL HEALTH AND OCCUPATIONAL OISEASES;1994-03
4 Sun Guirong;Wang Xiuguo(Jiamusi Medical College,Jiamusi 154003);Studies on the Hypoglycemic Action of Tetrandrine in Diabetic Rats[J];BASIC MEDICAL SCIENCES AND CLINICS;1996-03
5 Qian Lingmei,Wang Xiaoyun,Leng Jing.Department of Emergency,First affiliated Hospital of Nanjing Medical University,Nanjing 210029;Changes of apoptosis in rats of acute ischemic renal injury under the treatment of tetrandrine[J];JOURNAL OF EMERGENOY MEDICINE;1999-06
6 Guan Huaimin; Yiu Ruiyun;Huang Zhengwen et al.(Henan Provincial Chest Disease Hospital,Zhengzhou 450003);Influence of Tetrandrine on myocardium injury in dogs with experimental ischemia reperfusion[J];JOURNAL OF CLINICAL CARDIOLOGY;1998-05
7 ZHU Wu qiang ZEN Qiu tang CAO Lin sheng ZHANG Gui qing (Institute of Cardiovascular Disease,Union Hospital,Tongji Medical University,Wuhan 430022);Effect of tetrandrine on intracelluar Ca 2+ overload of cultured rat cardiomyocytes during hypoxia and reoxygenation[J];JOURNAL OF CLINICAL CARDIOLOGY;2000-02
8 Qian Lingmei; Wang XiaoyunDepartment of Nephrology,The First Affiliated Hospital of Nanjing Medical Univercity, Nanjing 210029;A Study on the Role of Tetrandrine for Acute Ischemic Renal Injury and the Relationship between Tetrandrine and Phospholipase A_2[J];Acta Universitatis Medicinalis Nanjing;1998-01
9 Xiao Jigao, et al.(Department of Pharmacology);Inhibitory Effects of Tetrandrine on Experimental Anterior Uveitis in Rabbits[J];ACTA ACADEMIAE MEDICINAE NANJING;1994-02
10 Xia Guojin;Yao Weixing;Liu Yan;et alDepartment of Pharmacology,School of Basic Medical Sciences;Tongji Medical University,Wuhan 430030;The Protective Effects of Tetrandrine on Myocardial Ischemia-reperfusion Injury in Isolated Rat Heart[J];Acta Universitatis Medictnae Tangji;1994-06
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 LI Xiang-hua (Medical School of Yangtze University,Jingzhou 434023,China)GAO Lin (Chemistry & environmental engineering School of Yangtze University,Jingzhou 434023,China)DU Ya-ming,WANG Wen-ying (Medical School of Yangtze University,Jingzhou 434023,China);Effect of Tetrandrine on Arsenic Content in Rats with Realgar Poisoning[J];Journal of Yangtze University(Natural Science Edition);2009-01
2 LI Xiang-hua~1, GAO Lin~2, YU Wan-gui~1, DU Yaming~1, ZHANG Yuan~1, WANG Wen-ying~1(MedicalSchool of Yangtze University, Hubei J ingzhou 434023,China; 2. Chemistry & environmental engineering School of Yangtze University, Hubei Jingzhou 434023, China);Effect of tetrandrine on arsenic content in rats with realgar poisoning[J];Chinese Journal of Hospital Pharmacy;2009-24
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 LIU Guo-qing, Sergio Algeri~* and Silvio Garattini~* (Department of Pharmacology, Nanjing College of Pharmacy) ~* "Mario Negri" Institute for Pharmacological Research, Milan;DEPLETION OF MONOAMINES IN THE RAT BY DL-TETRAHYDROPALMATINE[J];Acta Pharmaceutica Sinica;1983-09
2 LIU Guo-Qing, JIANG Ying, PENG Guang, IBRAHIM and ZHOU Le-Quan(Department of Pharmacology, Nanjing College of Pharmacy, Nanjing);EFFECT OF SOME ISOQUINOLINE ALKALOIDS ON MONOAMINES IN RAT BRAIN[J];Acta Pharmaceutica Sinica;1985-08
3 LI Feng-Lin, BAO Li-Hua and LI Wen-Han(Department of Pharmacology, Harbin Medical College, Harbin);THE EFFECTS OF BERBAMINE ON THE ISOLATED GUINEA-PIG ATRIA[J];Acta Pharmaceutica Sinica;1985-11
4 MA Zhi-Qing~(**) and LIU Guo-Oing(Department of Pharmacology, China Pharmaecutical University, Nanjing)Oraduate student of 1987;EFFECTS OF TETRAHYDROPALMATINE AND SOME OTHER ISOQUINOLINE ALKALOIDS ON THE UPTAKE OF [~3H]DOPAMINE INTO RAT STRIATAL SYNAPTOSOMES AND VESICULAR STORE[J];Acta Pharmaceutica Sinica;1987-05
5 CHEN Shu-Guang~(**), LIU Guo-Oing and MIN Zhi-Da(China Pharmaceutical University, Nanjing)1987 Graduate student;THE ACTIONS OF SOME TETRAHYDROISOQUINOLINE ALKALOIDS ON DOPAMINE AND SEROTONIN RECEPTORS IN RAT BRAIN[J];Acta Pharmaceutica Sinica;1987-05
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