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《Acta Academiae Medicinae Jiangxi》 2001-01
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Experimental Study on Brain Damage Following Extensive Bridging Vein Injury during Surgery

DENG Zhi-feng,YUAN Feng,WU Qi-ming, GUO Hua,LI Ming,ZHANG Ming-wen (Department of Neurosurgery, Second Affiliated Hospital, Jiangxi Medical College, Nanchang 330006,China; Department of Neurosurgery, People's Hospital of Hukou County, Hukou 332500,China  
Objective: Animal models were used for craniotomy.Brain retraction and drainage bridging veins were severed to induce postoperative congestive brain damage several hours later,and the specimens of brain were observed pathologically.Methods:Eighteen adult cats were divided into group A,B and C.In group A(five cats),after craniotomy all bridging veins of the left cerebral hemisphere were coagulated electrically near the superior sagittal sinus and five hours later the surgical wound was closed.In group B(five cats),a round plate weighing 50 g was pressed on the middle segment of the left Sylvian fissure for 5 hours and then the wound was closed.In group C(eight cats),both of the above interventions were performed.Twenty four hours later Evans blue was injected intravenously,then all animals were killed and the brains were removed for photography and pathological exam.Results:The ratios of Evans blue dye stained area to the total area of the left hemisphere of group A,B and C were 3.8%,2.94% and 24.84% respectively;significant difference were found between group A,B and group C respectively( P <0.01, P <0.01).In group C,obvious hemorrhage was observed not only in the subarachnoid space but also in the brain parenchyma,but without notable hemorrhage in group A and group B.Conclusion:The combination of severance of bridging veins and sustained brain retraction may lead to damage of BBB and increase its permeability.More attention should be paid on the preservation of bridging veins and reduction of brain retraction to diminish the occurrence of congestive brain damage.
【CateGory Index】: R651.1
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【Citations】
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1 Zhu Zhian,Feng Dongfu,Zhang Hong,et al.Department of Neurosurgery,Baogang Hospital,Shanghai Second Medical University,Shanghai (201900);Effect of magnesium sulfate on the permeability of blood-brain barrier after brain injury in rat[J];JOURNAL OF EMERGENOY MEDICINE;2000-01
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