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《Acta Academiae Medicinae Jiangxi》 2001-01
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Studies of Serum Levels of IL-2,sIL-2R, and TNF-α and ITs Significance in Patients with Hepatitis B

LIU Ren-rong, LIANG Chao, ZENG Fei, ZHANG Jian-ping, HE Jin-qiu (Department of microbiology ,Jiangxi Institute of Medical Science, Nanchang 330006,China; Department of Artificial Liver, The Ninth Hospital of Nanchang, Nangchang 330029,China)  
Objectives: To investigate the clinical significance of the levels of IL-2, sIL-2R and TNF-α in serum in patients with various types of viral hepatitis B (VHB), and the changing regularity of the levels of those three indexes in patients with severe VHB following treatment with artificial liver supporting system (ALSS). Methods: The levels of IL-2, sIL-2R and TNF-α in serum in patients with VHB ( n =99) and controls ( n =27) were determined by ELISA. HBeAg, hepatitis B virus-DNA (HBV-DNA) and alanine aminotransferase (ALT) in patients with VHB were determined. Results: ①The level of IL-2 were significantly lower in patients with chronic and severe VHB than in patients with acute VHB and controls ( P <0.01). ②The levels of sIL-2R and TNF-αwere significantly higher in patients with VHB than in controls ( P <0.01). ③In patients with severe VHB, the levels of sIL-2R and TNF-α were higher and the level of IL-2 were lower than those in acute and chronic VHB( P <0.01). ④The level of sIL-2R were higher in patients with positive HBeAg than in patients with negative HBeAg ( P <0.05). ⑤The levels of sIL-2R and TNF-α were higher in patients with positive HBV-DNA than in patients with negative HBV-DNA ( P <0.05, P <0.01). ⑥The levels of sIL-2R and TNF-α correlated negatively with the level of IL-2 ( P <0.01, P <0.05), and correlated positively with the level of ALT ( P <0.01), respectively. ⑦In patients with severe VHB, the level of IL-2 increased ( P <0.01), while the levels of sIL-2R and TNF-α decreased ( P <0.01) 24h after treatment with ALSS. All of the above indexes resumed 72h after the treatment. Conclusions: ①The abnormal changes of the levels of IL-2, sIL-2R and TNF-α in serum in patients with VHB are due to the continuously expression of hepatitis B virus, and advancement of the state of VHB. ②The treatment by ALSS for patients with severe VHB could improve the immune function just for a short time.
【CateGory Index】: R446.6;R512.62
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