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《Acta Academiae Medicinae Jiangxi》 2001-01
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Chromosomal Analysis of 120 Cases of Hydatidiform Mole and Its Clinical Significance

YU Shi-rong,TU Ling,LUAN Shu-qin,GUO Yu-pin,FU Xin-sheng,TANG Xiang-qun (Laboratory of Genetics,Jiangxi Provincial Women and Children Health Hospital; Department of Oncology,Jiangxi Provincial Women and Children Health Hospital,Nanchang 330006,China)  
Objective:To explore the clinical significance of chromosomal analysis of hydatidiform mole.Methods: Chromosomes of hydatidiform mole were prepared from curettage tissues by direct method and analsyed by,combination with pathology and clinical follow-up results (followed up at least for one year).Results:Among them 110 cases were of complete hydatidifom mole (CHM, all of which were diploid) and 10 cases of partial hydatidiform mole (PHM, all of which were triploid).Among the CHM,24 cases had malignant change (21.82%),but no malignant change was found among the PHM.The incidence of aneuploid in invasive mole was 87.50%(21/24),which was significantly higher than that in noninvasive mole (31/86,36.05%, P <0.01).It was also found that with aneuploid over 40% of the total mitotic figures accounted for 33.33%(8/24) in invasive moles,significantly higher than that in noninvasive moles (3/86,3.485%, P <0.01).The follow-up 11 cases with aneuploid over 40% of the total mitotic figures was as follows:8 cases of invasive mole having chemotherapy (7 cured,1 death); 3 cases of noninvasive mole having prophylactic chemotherapy without malignant change.This study shows that CHM has a stronger tendency to malignant change than PHM does and chromosomes serve to distinguish CHM from PHM.The frequency of appearance of aneuploid is correlated with malignancy.
【CateGory Index】: R737.33
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