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《Journal of Nanchang University(Medical Science)》 2012-08
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Detection of Serum IL-6,IL-10 and TNF-α in Children with Mycoplasma Pneumonia and Their Relationship with Disease Severity

LI Shou-jun,ZHANG Yun,WU Neng-shun,SUN Jian-hua(Department of Pediatrics,Yizheng People's Hospital,Yangzhou 211400,China)  
Objective To detect the expression of serum IL-6,IL-10 and TNF-α in children with Mycoplasma pneumonia and their relationship with disease severity.Methods Serum IL-6,IL-10 and TNF-α were detected using double sandwich ELISA in 60 children with acute phase of Mycoplasma pneumoniae(acute phase group),52 children with convalescence phase of Mycoplasma pneumoniae(convalescence phase group) and 30 healthy children(control group).The relationship between serum IL-6,IL-10 and TNF-α levels and disease severity was investigated.Results Compared with acute phase group,serum IL-6 and TNF-α levels significantly decreased and IL-10 levels obviously increased in convalescence phase group and control group(P0.05).There were no significant differences in serum IL-6,IL-10 and TNF-α levels between convalescence phase group and control group(P0.05).In acute phase group,serum IL-6 and TNF-α levels significantly increased and IL-10 levels obviously decreased in children with CPIS6 compared with children with CPIS≤6(P0.05 or P0.01).Conclusion Cytokine IL-6,IL-10 and TNF-α are involved in the pathogenesis of Mycoplasma pneumonia and are correlated with disease severity in children.The levels of IL-6,IL-10 and TNF-α can be used as indexes for evaluating the prognosis and treatment of Mycoplasma pneumonia.
【CateGory Index】: R725.6
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