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《Laboratory Medicine and Clinic》 2008-15
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Correlation analysis on several HBV indicators

ZHANG Hu-min1,YANG Jian1,FAN Yue-bang1,YANG Chuang2. 1. The People's Hospital of Yaan City,Yaan 625000,China; 2. Affiliated Hospital of Yaan Professional and Technological College,Yaan 625000,China  
Objective To explore the correlation of serum HBV markers (HBVM),PreS1 antigen and HBV DNA in patients with chronic viral hepatitis B.Methods Serum HBVM and PreS1 were determined with ELISA method while HBV DNA with real-time PCR assay.Results 126 out of 131 patients (96.2%) belonged to three typical HBV infected models:modelⅠwas HBsAg (+),HBeAg (+) and HBcAb (+);model Ⅱ was HBsAg (+),anti-HBe (+) and anti-HBc (+); model Ⅲ was HBsAg (+) and anti-HBc (+). Of 72 patients for modelⅠthe HBV-PreS1 positive rate was 83.3% (60/72),and the HBV DNA positive rate was 86.1% (62/72). Of 42 patients for modelsⅡ,the HBV-PreS1 positive rate was 28.6% (12/42) and the HBV DNA positive rate was 66.7% (28/42). Of 78 patients positive for HBV-PreS1,the HBV DNA positive rate was 87.2% (68/78),while 48 patients were negative for HBV-PreS1,the HBV DNA positive rate was 66.7%.Conclusion In the modelsⅠof the chronic viral hepatitis B patients,there is a closely positive correlation between PreS1 detection and HBV DNA. While in the modelsⅡ,HBV DNA detection has more significance than PreS1 detection. It is remarkable that HBV DNA has higher positive rate regardless of positive or negative for PreS1 in our test. Consequently,it showes that HBV DNA determination can be used as a gold standard to monitor the true state of HBV infection and replication and judge effectiveness of anti-virus treatment. HBV DNA detection should not be ignored fore patients negative for PreS1.
【CateGory Index】: R446.6;R450
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Xu-wen,LU Yu-yun.(Traditional Chinese Medicine Hospital of Conghua,Conghua 510900,China);APPLICATION OF THE DETECTION ON PRE-S_1 ANTIGEN AND HEPATITIS B VIRUS SERUM MARKERS[J];Modern Preventive Medicine;2007-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 WU Guochun,HE Zhonghua,CHENG Zhao jun et al.Nanjing Shanghai Meishan Hospital(Postcode:210039),Nanjing China.;Clinical Observation for Patients Infected with Hepatitis B Virus By Testing PreS_1[J];Hainan Medical Journal;2002-02
2 XIONG Jie,ZHU Min,WANG Feng-chang,QIAN Jiang-long,Chengdu Military General Hospital,Chengdu 610083;Analysis of Pre-S1 in Contrast to HBV Markers[J];Journal of Military Surgeon in Southwest China;2005-01
3 HUANG Ming-chun.Nanning Maternal and Child Health Care Hospital,Nanning 530011,China;Clinical significance of combined detection of PreS1 antigen and hepatitis B virus serum markers in parturient women[J];Laboratory Medicine and Clinic;2008-16
4 LI Xu-wen,LU Yu-yun.(Traditional Chinese Medicine Hospital of Conghua,Conghua 510900,China);APPLICATION OF THE DETECTION ON PRE-S_1 ANTIGEN AND HEPATITIS B VIRUS SERUM MARKERS[J];Modern Preventive Medicine;2007-03
5 LU Yu-yun,LI Xu-wen,ZENG Jun-rong,et al.(Conghua Branch,Guangzhou Medical College,Conghua 510925,China);STUDY ON RELATIONSHIP OF PRE-S1 ANTIGEN IN SERA OF PATIENTS WITH HBV AND CLINICAL TYPES[J];Modern Preventive Medicine;2008-11
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU En-quan, WANG Yong-mei, LI Ke-jun.(Central Hospital Affiliated to Shen Yang Medical College 110024);Contrastive detection and clinic analysis to HBV serum symbols、HBV-DNA and HBV preS_1-Ag of 100 patients[J];Chinese Journal of Clinical Hepatology;2002-04
2 CHENG Gang, HE Yunshao, ZHOU Xinyu. Da An Gene Diagnostic Center, Sun Yetsen University of Medical Science, Guangzhou 510089;Fluorescence quantitative PCR and its application in detection of hepatitis B virus[J];Chinese Journal of Laboratory Medicine;1999-03
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