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《Journal of Jinzhou Medical Coilege》 1993-01
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A STUDY OF THE REGULATION OF THYROID HORMONES AND ANALOGS ON THE T_45′ DEIODINASE IN DIFFERENT TISSUES OF THE RAT

Yu Hongru et al(Department of Biochemistry, Jinzhou Medical College)  
The role of T45′ deiodinase is to convey the local tissue T_4 to T_3 In this experiment, we used ~(125)Ⅰ T_4 a′s substrate and the method of thinlayer chromtoagraphy to study the regulation of thyroid hormones (T_3.T_4)and analogs(DIT.MIT)on the T_45′ deiodinase in the cerrebral cortex, liver and kinde of the rat. These results demonstrated: In the cerebral cortex of the rat, T_4 inhibited the T_45′ deiodinase activty, Ta had no effects on it; In the liver and kindey of the rat, T_3 and T_4 both increased the T_45′ deiodinase activity, but T_3 proved to be a more potent enzyme inducer than T_4; DIT, MIT had no effects on T_45′deiodinase in the three organs. These studies might suggest that the regulation mechanisms of T_45′ deiodinase in the cerebral cortex and liver, kindey of the rat were different , the regulation of T_45′ deiodi nase might be local rather than'systemic.
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【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Zhang Dianshi et al(Biochemistry Department,Jinzhou Medical College);THE STUDY OF T_45’DEIODINASE ACTIVITY IN THE AGING RAT PITUITARY AND LIVER[J];JOURNAL OF JINZHOU MEDICAL COLLEGE;1996-03
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