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《Journal of Liaoning Medical University》 2007-01
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Effect of Manganese on Cardiomyopathy of Diabetic Rats

KANG Yan-ping,WANG Guo-qiu,QI Zhi-min,LI Shu-yun (Liaoning Medical University,Jinzhou 121001 China)  
Objective This paper is to lbserve the protecting roles of Manganese on myocardium of Ⅱ diabetic rat and to explore their mechanisms.Methods Experimental animals were divided in to three groups: the control group,the diabetic group and the Manganese supplied groups.The blood sugar level of each group was deteted when the rats had been fed for 4 weeks,6 weeks,10 weeks and 14 weeks.We duplicated diabetic rat pattern in 8 weeks and measured MDA content of myocardium tissue and Mn-SOD activities and retained myocardium tissue to make electron microscope observation.Results Compared with that of the diabetic group,MDA content of myocardium tissue Manganese supplied group significantly decreased,but Mn-SOD activities greatly increasod.Through pathological examination,it was found that Manganese supplied group had less inner root of tunica intima of myocardial micro-vessel and smaller basilar membrane thickness than the diabetic groups.Conclusions Manganese supplement,which is related to the acceleration of anti-oxidation action,can help recover myocardial injury of Ⅱ diabetes.
【CateGory Index】: R587.1
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