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《Journal of Liaoning Medical University》 2007-01
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A Study on the Relationship Between αv Integrin and Ovarian Cancer Cell Proliferation and Apoptosis

TANG Yan,ZHANG Shuang(Department of Obstetrics and Gynaecology,the First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001 China)  
Objective This paper is to study the relationship between α v integrin and ovarian cancer cell proliferation and apoptosis in vitro.Methods The proliferation of cells was detected by MTT method;morphological and ultrastructure changes were observed by acridine orange(AO) staining;cell cycle and apoptotic percentage were analyzed by flow Cytometry(FCM).Results Sc-9969 could inhibit the proliferation of HO-8910 cells as direct relation of concentrations and times.Apoptosis morphology was observed in sc-9969 groups.The flow cytometry showed that the proportion of G1 phase and the apoptotic rate were increased significantly in Sc-9969 groups,and the proportion of S phase and G2/M phase was reduced.Conclusions Integrin α v subunit will be able to delay the apoptosis of Ovarian cancer and promote cell survival.
【CateGory Index】: R737.31
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