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《Journal of Liaoning Medical University》 2008-01
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The Relationship Between the Expression of CD44V6,HIF-1α,VEGF in NSCLC and the Behaviour of the Invasion,Metastasis of NSCLC

ZHANG Xiuliang ZHU Zhitu HA Minwen Department of Turnout Medicine,the First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001 China  
Objective This thesis aims to evaluate the relationship between the expression of CD44V6,HIF-1α,VEGF in non -small cell lung cancer(NSCLC)and the behaviour of the invasion,metastasis of NSCLC.Methods The expressions of CD44V6, HIF-1αand VEGF were detected by immunohistochemical method.Results The positive expression of CD44V6,HIF-1α,VEGF in NSCLC was demonstrated in 85.07%,61.19% and 74.63% respectively.The expression levels of CD44V6,HIF-1α,VEGF were associated with tumor size,pathotype,histological differentiation,lymph nodal metastas,TNM stage(P0.05),and there were significant correlations among them.The combined positive expression of CD44V6,HIF-1α,and VEGF was related to lymph nodal metastas,TNM stage(P0.05).Conclusions The expression of CD44V6,HIF-1α,VEGF in NSCLC correlates closely with the behaviour of the invasion,metastasis of NSCLC.
【Fund】: 辽宁省科学技术计划立项课题资助(编号:2007225005-13)
【CateGory Index】: R734.2
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【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Yin-mei, TANG Xiu-fa. (Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China);Research progress in invasion of ameloblastoma[J];International Journal of Stomatology;2008-S1
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 ZHU Zhi-Hua1, RONG Tie-Hua1, ZENG Can-Guang1, WU Qiu-Liang2, MA Yun3, HUANG Xiao-Ping1, LI Bao-Jiang1, ZHANG Peng-Yuan1, ZHAO Jin-Ming1, HU Wei1, ZHANG Shi-Yi1, YU Hui1, MA Guo-Wei1, ZHANG Lan-Jun1, WEN Zhe-Sheng1, FU Jian-Hua1, LONG Hao1 1. Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China 2. Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China 3. Center of Experimental Animal, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P.R.China;Vascular Endothelial Growth Factor Expression and Microvessel Density in StageⅠ-Ⅱ Non-small Cell Lung Cancer and Their Prognostic Significances[J];Chinese Journal of Cancer;2005-07
2 WENG Mi-Xia1, WU Cui-Huan2, YANG Xiu-Ping1 1. Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P. R. China 2. Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China;Expression and Significance of E-cadherin, CD44v6, and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Cancer[J];Chinese Journal of Cancer;2008-02
3 WANG Zitong, ZHANG Haiqing, LI Shiye. Department of Thoracic Surgery, Beijing Thoracic tumour and Tuberculosis Hospital, Beijing 101149, P.R.China;Expression and clinical significance of nm23-H1 and CD44v6 in non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2002-04
4 LI Bin, CAO Xuewen, ZHANG Jianhua, JIANG Junwei, YANG Yongzhu, GOU Yunjiu. Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital, Lanzhou Medical College, Lanzhou, Gansu 730030, P.R.China;Expression and clinical significance of vascular endothelial growth factor in human non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2004-02
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