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《Journal of Liaoning Medical University》 2008-01
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Cord Blood lgE Level Correlation of Development of Atopic Diseases in Infants

SUN Yingjian Obstetrics and Gynecology Department,the Second People's Hospital of Fushun Fushun 113001 China; WEI Qingyu ZHU Xiaoming Shenyang 202 Hospital,Shenyang 110000 China; CAO Fabin Shenyang Institute of Chemical and Technology,Shenyang 110142 China  
Objective Assessment of the the positive predictive value the infant umbilical cord blood IgE level has on allergic disease.Methods By using fluorescence enzyme immunoassay to measure cord blood IgE value of 134 cases.Born after 1 month,3 months,6 months,1 year and 3 years,134(100%)of the infants were followed up by telephone interview or were asked to come to clinic five times(completed 4 times till now).Recording in details the actual condition of infants with eczema and repeated asthma and urticaria,or other allergic diseases.All data were obtained by using EXCEL software for statistical analysis.Results Among the 100% Follow-up 134 case interview,there are 42 cases appearing normal,92 cases having allergic reactions,including 84 patients (68.7%)of cord blood IgE levels greater than 0.35 KU/L of infants,in which occurred 63 cases(47.0%)of baby Eczema,25 ca- ses(18.7%)of urticaria,12 cases(9.0%)of recurrent wheezing.Cord blood IgE levels of infants less than 0.35 KU/L developed allergic disease for eight cases(6.0%),in which there were three cases of infant eczema(2.2%),four cases(3.0%)of urticaria, and four cases(3.0%)of recurrent wheezing.Conclusions The results suggested that cord blood lgE levels increased susceptibility of infants allergic diseases,particularly baby eczema and urticaria.Cord blood IgE levels connecting with family history has higher pos- itive predictive values of allergic diseases of infant allergy.
【CateGory Index】: R725.9
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