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《Journal of Liaoning Medical University》 2009-01
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Effect of Procyanidin on Expression of nNOS in Type 2 Diabetes Mellitus Rats with Focal Cerebral Ischemia

SONG Xiaowei,MIN Lianqiu(Department of Neurology,the First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001 China)  
Objective To investigate effects of procyanidin(PC) on type 2 diabetes mellitus rats with focal cerebral ischemia about neuronal NO synthase in hippocampus tissue.Methods Sixty-six SD rats were divided into sham-operation,model,and PC group.After ischemia for 3 h,6 h,12 h,24 h,48 h,the expression of nNOS was examined by using immunohistochemical SABC method.Results There was mass expression of nNOS positive-cells in the hippocampus tissue after ischemia.They appeared 3 hours after ischemia and increased progressively,reached the peak 6 hours after ischemia and then gradually decreased.At the same time,the expression of nNOS positive-cells was higher in model group than that in sham operated group(P0.01).The expression was lower in PC group than that in model group(P0.01),but there was no significant difference between the PC group and sham operated group(P0.05).Conclusions PC can reduce the activity of nNOS in hippocampus tissue of the type 2 diabetes mellitus rats with focal cerebral ischemia.
【Fund】: 辽宁省教育厅高等学校科学研究项目(NO05L137);; 锦州市科学技术计划项目(NO05A1E31)
【CateGory Index】: R285.5
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