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《Journal of Liaoning Medical University》 2009-01
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Effects of U0126 on Aquaporin-4 Expression in Rat Brains after Cerebral Hemorrhage Injury

ZHANG Shuheng,YI Fuxin,NI Weimin,MENG Fei,YE Zhijun(Department of Neurosurgery,the First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001 China)  
Objective To study the effect of U0126 on brain edema and the expression of aquaporin 4(AQP4) in rat brains after cerebral hemorrhage injury.Methods Totally 72 healthy male SD rats were divided randomly into hemorrhage group,U0126 group DMSO group,and normal group.Rats in hemorrhage group,DMSO group and treatment group underwent stereotaxic injection of auto-non-anticoagulated artery blood into the caudate.Thirty minutes before operation,the rats in treatment group were injected into vena caudalis with U0126,while rats in hemorrhage group accepted normal saline,and rats in DMSO group accepted normal DMSO.24 hours after the operation,the water content and Evans Blue in rat brains were determined as to exploring the degree of brain edema Immunohisto chemistry,Westernblot technique was applied to detect AQP4,P-ERK1 /2.Results Compared with normal group,the water content and AQP4 expression in hemorrhage group were increased obviously.The water content and AQP4 expression in U0126 group(protein: 147.7±1.2) were lower than those in hemorrhage group(protein: 156.8±0.8,P0.01).Meanwhile,P-ERK1 /2 in U0126 group was lower than those in hemorrhage group.Conclusions There should be evident brain edema after cerebral hemorrhage injury,accompanied by the over-expression of AQP4.U0126 pretreatment should be able to inhibit the over-expression of AQP4 and reduce the brain edema.
【CateGory Index】: R743.34
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Chinese Journal Full-text Database 10 Hits
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