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《Journal of Liaoning Medical University》 2009-01
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Effects of U0126 on Aquaporin-4 Expression in Rat Brains after Cerebral Hemorrhage Injury

ZHANG Shuheng,YI Fuxin,NI Weimin,MENG Fei,YE Zhijun(Department of Neurosurgery,the First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001 China)  
Objective To study the effect of U0126 on brain edema and the expression of aquaporin 4(AQP4) in rat brains after cerebral hemorrhage injury.Methods Totally 72 healthy male SD rats were divided randomly into hemorrhage group,U0126 group DMSO group,and normal group.Rats in hemorrhage group,DMSO group and treatment group underwent stereotaxic injection of auto-non-anticoagulated artery blood into the caudate.Thirty minutes before operation,the rats in treatment group were injected into vena caudalis with U0126,while rats in hemorrhage group accepted normal saline,and rats in DMSO group accepted normal DMSO.24 hours after the operation,the water content and Evans Blue in rat brains were determined as to exploring the degree of brain edema Immunohisto chemistry,Westernblot technique was applied to detect AQP4,P-ERK1 /2.Results Compared with normal group,the water content and AQP4 expression in hemorrhage group were increased obviously.The water content and AQP4 expression in U0126 group(protein: 147.7±1.2) were lower than those in hemorrhage group(protein: 156.8±0.8,P0.01).Meanwhile,P-ERK1 /2 in U0126 group was lower than those in hemorrhage group.Conclusions There should be evident brain edema after cerebral hemorrhage injury,accompanied by the over-expression of AQP4.U0126 pretreatment should be able to inhibit the over-expression of AQP4 and reduce the brain edema.
【CateGory Index】: R743.34
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Xiao-wen, KE Jin-xing, CHEN Dai-lun, TAO Zhong-fen, SUN Wei, HUANG Wen-qi, WANG Li, XIAO Tao-yuan (Department of Center Laboratory, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China);Study of aquaporin protein 4 with cerebral pathology and pathogenesis of high altitude response[J];Acta Academiae Medicinae Militaris Tertiae;2005-16
2 ZHANG Yu-sheng,ZENG Jin-sheng. Department of Neurology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;Aquaporin 9 and brain diseases[J];International Journal of Internal Medicine;2008-09
3 WANG Sheng-Wu, LI Xiao-Gang. Department of Neurology,Fourth People's Hospital of Zigong, Zigong, Shichuan 643000, China;Correlation between aquaporin-4 expression and the change of blood-brain barrier ultramicrostructure after cerebral hemorrhage in rats[J];Journal of International Neurology and Neurosurgery;2009-01
4 SUN Bin YI Fu-xin ZHANG Shu-heng (Department of Neurosurgery,the First Affiliated Hospital,Liaoning Medical University,Jinzhoa 121001 China);Effect of Yidalafeng on Blood-brain Barrier Permeability and AQP4 Expression after Experimental Cerebral Hemorrhage in Rats[J];Journal of Liaoning Medical University;2007-06
5 TENG Wei-Yu,GAO Yan,TIAN Li,LIU Hong-Li,GE Yu-Song,and ZHANG ChaoDong (Department of Neurology,the First Affiliated Hospital,China Medical University,Shengyang 110001,China);The Relationship Between Aquaporin-4 mRNA Expression and Blood-Brain Barrier Permeability After Experimental Cerebral Hemorrhage in Rats[J];Chinese Journal of Arteriosclerosis;2006-04
6 CHENG Gui-Ling~1 LV Yong-Tao~1 CHI Zhao-Fu~2 ~1Department of Neurology,The Traffic Hospital of Shandong Province,Jinan 250031;~2Qilu Hospital,Shangdong University,Jinan 250012,China;The Change of aquaporin-4 Expression in Perihematomal Tissue of Intracerebral Hemorrhage Patients[J];Chinese Journal of Clinical Neurosciences;2008-06
7 DUN Sai-hong1,GUO Yang2(1.China Medical University,Shenyang 110001,China; 2.Dept.of Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,China);Effect of Nimotop on expression of AQP_4 mRNA after ischemic brain edema in rats[J];Practical Pharmacy and Clinical Remedies;2007-03
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9 Zhao Hejian,Gao Lin,He Weiya.Department of Neurology,Huaihe Hospital of Henan University,Kaifeng 475001,China;Effect of GM1 on expression of AQP4-mRNA after ischemic brain edema in rats[J];Chinese Journal of Practical Nervous Diseases;2009-20
10 LIAN Xiao-yu,ZHANG Xiu-feng,XUAN Zhao-bo,GU Zhi-cheng(Department of Neurosurgery,the First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China);Aquaporin-4 expression in rat brain edema after subarachnoid hemorrhage and effect of Nimodipine on aquaporin-4 expression[J];Heilongjiang Medicine and Pharmacy;2009-06
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