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《Journal of Liaoning Medical University》 2009-01
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Inhibition of Tetramethylpyrazine on Small Cell Lung Carcinomas,Microvessel Growth and VEGF Expression in Mice

LIU Zhiliang1,CUI Lunbo2(1.Liaoning University of Traditional Chinese Medicine,Shenyang 110001 China;2.Donghuan Hospital of Dashiqiao City,Dashiqiao 115103 China)  
Objective To explore the inhibition and mechanism of tetramethylpyrazine on the solid tumor and its vascular growth.Methods The C57BL mice with small cell lung carcinomas were injected with the extract of tetramethylpyrazine(100,200 mg/kg /d) at abdomen for 21 d.Then the volume of the tumor,the weight,the numbers of the metastatic foci and the microvessel density(MVD) were determinated.The expression of the vascular endothelial growth factor(VEGF) in tumor was analyzed with Western Blot and immunohistochemical test.Results Tetramethylpyrazine could remarkably reduce the tumor volume,weight,number of the metastatic foci,MVD of tumor and expression of VEGF.Conclusions Tetramethylpyrazine can remarkably inhibit small cell lung carcinoma growth and metastasis in mice.Its mechanism might be associated with inhibiting expression of VEGF and reducing MVD.
【CateGory Index】： R734.2
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