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《Journal of Liaoning Medical University》 2009-01
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Effect of Zhuyuhuatan Oral Liquid on the Brain Water Content and SOD of Rats Following Intracerebral Hemorrhage

LU Hong1,WANG Guimin2(1.Department of Neurology,Jinzhou Central Hospital;2.Department of Chinese Medicine,Liaoning Medical University,Jinzhou 121001 China)  
Objective To examine the effects of Zhuyuhuatan oral liquid on brain water content and the activity of superoxide dimutase(SOD) following intracerebral hemorrhage(ICH) in rats and its possible mechanism.Methods 90 SD rats were randomly divided into 3 groups: Zhuyuhuatan oral liquid,ICH and sham group.The rat model of ICH was established by injection of autologous blood into the caudate nucleus.At a different time,the brain water content and the activity of superoxide dimutase(SOD) were examined separately.Results Treatment of Zhuyuhuatan oral liquid markedly reduced brain water content in comparison to the ICH group,while the activity of superoxide dimutase(SOD)was obviously higher in the Zhuyuhuatan oral liquid group than that in the ICH group.Conclusions Zhuyuhuatantang can protect the brain through reducing brain water content and increase the activity of superoxide dimutase(SOD).
【CateGory Index】: R285.5
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