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《Journal of Liaoning Medical University》 2009-01
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Protective Effects of Irbesartan on the Apoptosis in Myocardial Cell of Rats with Ischemia Reperfusion Injury

ZHANG Bo(Jinzhou Central Hospital,Jinzhou 121001 China)  
Objective To study the effect and mechanism of irbesartan on cardiac myocyte apoptosis in myocardial ischemia reperfusion injury with isolated rat hearts.Methods The hearts of 48 SD rats were isolated,linked to Langendorff perfusion apparatus,and randomly divided into 3 equal groups: control group,ischemia / reperfusion(I/R) group and irbesartan group.First,8 rats in each group were subjected to ischemia for 30 minutes followed by reperfusion for 60 minutes.Samples of left ventricle were taken out to detect the activity of total superxide dismutase and malondialdehyde.And then,the other 8 rats in each group were subjected to 120 minutes' reperfusion.Myocardium apoptosis were investigated in each group.Results The index of myocyte apoptosis(AI) and the contents of malondialdehyde were significantly lower(P0.01) in the irbesartan group.The activity of superxide dismutase was increased after irbesartan perfusion.Conclusions Irbesartan can protect the heart from ischemic and reperfused injury by decreasing myocyte apoptosis.The protective effect may be related to reducing the produce of oxygen-derived free radicals.
【CateGory Index】: R96
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