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《Journal of Liaoning Medical University》 2009-01
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Protective Effects of Irbesartan on the Apoptosis in Myocardial Cell of Rats with Ischemia Reperfusion Injury

ZHANG Bo(Jinzhou Central Hospital,Jinzhou 121001 China)  
Objective To study the effect and mechanism of irbesartan on cardiac myocyte apoptosis in myocardial ischemia reperfusion injury with isolated rat hearts.Methods The hearts of 48 SD rats were isolated,linked to Langendorff perfusion apparatus,and randomly divided into 3 equal groups: control group,ischemia / reperfusion(I/R) group and irbesartan group.First,8 rats in each group were subjected to ischemia for 30 minutes followed by reperfusion for 60 minutes.Samples of left ventricle were taken out to detect the activity of total superxide dismutase and malondialdehyde.And then,the other 8 rats in each group were subjected to 120 minutes' reperfusion.Myocardium apoptosis were investigated in each group.Results The index of myocyte apoptosis(AI) and the contents of malondialdehyde were significantly lower(P0.01) in the irbesartan group.The activity of superxide dismutase was increased after irbesartan perfusion.Conclusions Irbesartan can protect the heart from ischemic and reperfused injury by decreasing myocyte apoptosis.The protective effect may be related to reducing the produce of oxygen-derived free radicals.
【CateGory Index】: R96
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Zhang Hui,Dong Jianfeng,Wang Xiaoyin1,Niu Shulei1,Bo Aihua1(Department of Anatomy,Hebei North University,Zhangjiakou 075029,China);EFFECTS OF LIGUSTRAZINE ON PARIETAL CORTICAL NEURON ULTRASTRUCTURE AND CASPASE-9 mRNA EXPRESSION IN CEREBRAL ISCHEMIA REPERFUSION(CIR)RAT[J];Chinese Journal of Histochemistry and Cytochemistry;2009-04
2 CHEN Yu-feng,LI Xing-san,LIANG Zhi-shan.Department of Cardiology,the Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou 545005),China.;Effect of irbesartan on expression of P-selection in the myocardial ischemia-reperfusion areas of rabbits[J];Guangxi Medical Journal;2005-12
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6 ZHAO Qiu-zhen,LI Wei,BO Ai-hua,ZHANG Hui(Department of Anatomy,Hebei North University,Zhangjiakou 075029,China);Neuron Ulstructure and Protective Effects of Ligustrazine in Rats Cortex after Cerebral Ischemia Reperfusion[J];Lishizhen Medicine and Materia Medica Research;2009-03
7 He X, Tao GZ, Qi ZM. 1Department of Cardiology, 2Department of Pathology, First Hospital Affiliated to Liaoning Medical University, Jinzhou 121001, Liaoning Province, China;Inhibitory effects of magnesium gluconate on the apoptosis of myocardial cells in rats with ischemia reperfusion injury in vitro[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-08
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