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《Journal of Liaoning Medical University》 2009-01
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Preparation of Solid Lipid Nanoparticles Loaded with Ibuprofen

WU Dongdong1,WEI Zhongmin1,PANG Xiujuan2,YU Kefu2(1.The First Affiliated Hospital of Liaoning Medical University,Jinzhou 121000 China;2.Pharmacy School,Shenyang Pharmaceutical University,Shenyang 110016 China)  
Objective To prepare solid lipid nanoparticles(SLN) loaded with ibuprofen and improve its prescription.Methods Ibuprofen-SLN was prepared by emulsification dispersion-ultrasonication method.Orthogonal experiment design was conducted to select the optimal formulation,which was based on the encapsulate efficiency(EE%).Results Based on the Orthogonal experiment,the optimal formulation were Ibuprofen 0.05 g,Pluronic F-68 0.35 g,1-butanol 2 mL,lecithin 0.15 g,glyceryl monostearate 0.05 g.Conclusions The results suggested that Ibuprofen-SLN prepared by this prescription and technology was consistent with the demand of nano-preparations.
【CateGory Index】: R94
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