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《Journal of Liaoning Medical University》 2010-01
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The Treatment Effect and Mechanism Research of Carnitine-orotate on Gastric Acid Left

HE Jianru1,WANG Lijun2,SU Yuhong1(1.Liaoning Medical University,Jinzhou 121001 China;2.Chongqing Police Station,Chongqing 400020 China)  
Objective To observe the therapeutic effect of Carnitine-orotate on gastric ulcer and discuss the relevant mechanism.Methods HE dyeing observation was applied into the rat gastric healing process.Elisa test IL-8,IL-10 expression.Immunohistochemical method was applied to test the expression of EGF.Results ①Carnitine-orotate can heal gastric ulcer.②Carnitine-orotate can reduce MDA content of the organization,Strengthen SOD,Through anti-oxidation stress treatment ulcers.③Carnitine-orotate inhibit inflammatory factor IL-8,10 expression and play a role in anti-oxidation.④Carnitine-orotate resistance and promote EGF.Conclusions Carnitine-orotate is effective to treat stomach ulcers mainly through anti-oxidation stresses and promote the expression of EGF.
【Fund】: 辽宁省教育厅重点实验室项目 编号:2009506
【CateGory Index】: R965
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