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《Journal of Liaoning Medical University》 2012-01
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Expression and Significance of PTCH in Renal Clear Cell Carcinoma

LIANG Bo,LI Xiaoming,GUO Min(Department of Histology and Embryology,Liaoning Medical University,Jinzhou 121001 China)  
Objective To observe the expression of PTCH in renal clear cell carcinoma(RCCC) and normal renal tissues,and to investigate the correlation between the abnormal expression of PTCH and RCCC.Methods Expression of PTCH was detected by immunohistochemistry in RCCC and normal kidney.Results Lower PTCH was expressed in normal kidney.Up-regulation of PTCH was observed significantly in RCCC.The increased PTCH level was disassociated with age,gender,and tumorous size of RCCC.Conclusions Up-regulation of PTCH in Hedgehog signaling pathway might be involved in RCCC,and it might have an important role in development and progression process of RCCC.
【Fund】: 辽宁省教育厅科技研究资助项目 编号:L2010269
【CateGory Index】: R737.11
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