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《Journal of Liaoning Medical University》 2012-01
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The Effect of Ipriflavone on Nitric Oxide and Nitric Oxide Synthase in the Rabbit Mandibular Distraction Osteogenesis

LOU Yue1,ZHANG Zhichun1,2,ZOU Jirong2(1.Liaoning Medical University;2.Jinzhou Dental Hospital,Jinzhou 121001 China)  
Objective To explore the effect of synthetic phytoestrogen plant estrogen ipriflavone on nitric oxide and nitric oxide synthase in the rabbit mandibular distraction osteogenesis.Methods 40 healthy Japanese white rabbits were selected and randomly divided into the control group and the experimental group,20 rabbits respectively.50 mg/(kg·d) ipriflavone was injected into the rabbits of the experimental group after mandibular distraction osteogenesis.Determination of serum NO concentrations was operated a day,a week,two weeks and four weeks after the distraction respectively.Meanwhile,Immunohistochemistry was used to observe NOS in different periods.Results The concentrations of NO and NOS were higher in the experimental group and the difference was statistically significant(P0.05).New bones were formed earlier than those in the control group during the same period.Conclusion Ipriflavone could accelerate new bone formation and mineralization,and reduce bone healing by improving serum concentration of NO after the distraction osteogenesis.
【Fund】: 辽宁省自然科学基金项目 编号:2009A463
【CateGory Index】: R782.2
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