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《Journal of Liaoning Medical University》 2013-01
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A Systematic Review on the Efficacy and Adverse Effects of BCG with Chemotherapy Drug and Intravesical BCG in Preventing the Postoperative Recurrence of High-risk Normuscle Invasive Bladder Cancer

NING Jinzhuo,JIANG Shuchuan(Department of Urology,Yijishan Hospital of Wannan Medical College,Wuhu 241000 China)  
Objective To review the efficacy and adverse effects of BCG with chemotherapy drug compared with intravesical BCG alone in preventing the postoperative recurrence of normuscle invasive bladder cancer.Methods By Retrieving the Cochrane Library,Pubmed,EMbase,Chinese Biomedical Literature Database,Chinese Journal Full-text Database,Wanfang Database and other online databases,and manually searching the Chinese Journal of Surgery,Chinese Journal of Urology,Chinese Journal of Oncology,Journal of Clinical Urology and other magazines.Literatures would be screened in accordance with the inclusion criteria by two reviewers,completing quality assessment,data extraction and making Meta-analysis via RevMan 5.0.Results A total of 13 articles collected,meta-analysis results showed that the recurrence rate of bladder tumor of BCG-chemotherapy group is less than the BCG group,the subgroup analysis showed that both the recurrence rates of normuscle invasive bladder cancer of mitomycin combined with intravesical BCG Ta and T1 and pirarubicin combined with intravesical BCG are lower than BCG alone.There was no statistical difference between epirubicin or gemcitabine combined with intravesical BCG and BCG in normuscle invasive bladder cancer(P0.05),concerning the adverse effects rate of the intravesical instillation,the difference between BCG-chemotherapy drug and BCG was no statistical significance either(P0.05).Conclusion BCG-chemotherapy is superior to BCG alone in preventing the postoperative recurrence of normuscle invasive bladder cancer,especially BCG combined with mitomycin(prevention of Ta and T1 high-risk normuscle invasive bladder cancer) or pirarubicin(prevention of high-risk normuscle invasive bladder cancer) bladder tumor.
【CateGory Index】: R737.14
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