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《Journal of Jinzhou Medical University》 2017-01
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Expression of Actin and Prdx4 Protein in Ectopic Endometrium Tissue

CHEN Gengbiao;LIU Yingfen;Pathology Department,Sun Yat-sen Memorial Hospital of Sun Yat-sen University;Rehabilitation Department,Guangdong Province Hospital of TCM;  
Objective To study the expression level of actin and Prdx4 in ectopic endometrium tissue. Methods 35 cases of ectopic endometrium tissue were collected as the ectopic group; the other collection of 40 cases of normal endometrium tissue was as the normal group. Actin and Prdx4 expression level were detected by immunohistochemistry and Western Blot method in two groups. Results Immunohistochemistry showed that positive rate of actin expression in endometrial tissue from endometriosis patients was88. 57%,which was significantly higher than that in the normal endometrial tissue,while positive rate of Prdx4 expression was 40%,which was significantly lower than that of the normal group. There was a statistically significant difference between two groups( P 0. 05). Western Blot method also showed that patients with endometriosis have obvious high expression level of actin and low expression level of Prdx4. Compared with the normal group,there were statistically significant differences( P 0. 05). Conclusion Actin may play an important role in the process of endometriosis,and Prdx4 may participate in retreat of endometriosis.
【CateGory Index】: R362
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