The Clinical Significance of TSH Receptor Antibody Assay in Patients with Thyroid Disease
YUAN Lihua;SHI Dan;Department of Endocrinology,Rich Hospital of Nantong;
Objective To study the clinical significance of TSH receptor antibody assay( TRAb) in patients with thyroid disease.Methods 85 patients with thyroid disease treated in our hospital from September 2012 to September 2014 were selected as the study group,they were divided into autoimmune thyroid disease( GD) group with 39 cases and non-GD group with 46 cases according to the type of disease,and 45 cases of healthy person were also selected over the same period( the control group). TRAb of all inductees were detected in radioimmunoassay,and thyroid stimulating hormone( TSH) levels of all groups were compared. Results TSH levels of the study group were significantly lower than those of the control group. TRAb,FT3 and FT4 levels and the positive rate of TPOAb and TGAb were significantly higher than those of the control group,and the differences were statistically significant( P0. 05). TSH levels of GD initially diagnosed were significantly lower than those of GD recurrence. TRAb,FT3 and FT4 levels and the positive rate of TGAb were significantly higher than those of GD recurrence,and the differences were statistically significant( P0. 05). TRAb in simple goiter and nodular goiter of non-GD group were expressed as negative,the positive rates of TRAb in subacute thyroiditis and Hashimoto's disease( HD) were relatively high( χ~2= 9. 114,P = 0. 011). Conclusion TRAb is valuable in diagnosing GD,but HD and subacute thyroiditis should be excluded.
【CateGory Index】： R581