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《JOURNAL OF JINZHOU MEDICAL COLLEGE》 1997-01
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IMMUNORYTOCHEMICAL STVOLES ON THE SEROTONIN NEURONS IN NUCLEUS RAPHE DORSALIS OF RATS WITH EXPERIMENTAL FLUOROSIS

Chen Xuejun,et al (Depertment of Pathology,Jin zhou Medical College)  
The male rats model of chronic fluorosis were established with administration of large dose fluoride in drinking water.The nucleus raphe dorsalis(NRD)in the brain stem was obserred with the light and electron microslope and the qualitative and quantitative analysis of serotonin(5-HT)neurous in NRD with immurocytochemical technique was made.The results showed that the ultrastructures of the neurons in NRD changed in fluorosis rats.The ratio of the nucleus in NRO changed in fluorosis rats.The ratio of the nucleus in the cytoplasm increased the heterogenous chromasome in nuclei increased and accumulated around,mitochondria expanded, crest broke down or disappeared,cisternae of rough endoplasmic reticula and flat capsules of Golgi complex bodies expanded.lmmunocyto chemistry revealed that the number of 5_HT positive particles in neurons decreased in fluorosis group,Some 5-HT like neuron body becomes dystrophy or swells.With cellimage analysis,the 5-HT centents in the 5-HT neurons,decreased significantly in fluorosis group,which suggests that the administration of larger does of fluonide causes direct damages to the central serotonin neurons and may inhibit its from producing 5-HT.
【CateGory Index】: R-332
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