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《JOURNAL OF JINZHOU MEDICAL COLLEGE》 1997-01
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THE COMPARISON RESEARCH ON TREATMENT EFFECTS OF PAMSHA AND BCG COMBINED RESPECTIVELY WITH S-180 VACCINE ON TUMOR-BEARING MICE

Zhang Mingce,et al (Department of Microbiology)  
Under the different treatments of PA-MSHA and BCG combined respectively with irration S-180 tumor cells on tumor-bearing mice(1×10 7 active S-180 cells),the Active Specific Immunotherapy effects and immune cell activities were investigated.The results showed that PA-MSHA alone,its combined and BCG-combinde all decreased the growth of local implanted tumor (P0 05),PA-MSHA-combined appearing the highest inhibition ratio(P0 01).Peritoneal exudate cells (MΦ)in PA-MSHA-combined treated mice grew more efficient in suppression of S-180 cell proliferation and the splenic cells showed more proliferative ability(P0 01).Contrastively,MΦ in BCG-combined treated mice were similar to those above;the splenic cells,however,failed to show the same ability (P0 05).All these results suggested that PA-MSHA might synergy more efficiently than BCG with tumor cell vaccine to promote the effect of antitumor ASI.
【CateGory Index】: R73-3
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