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《Research and Practice on Chinese Medicines》 2013-01
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Study on Neural Protective Function of Duhuo Experimental Allergic Encephalomyelitis

ZHAO Dan,ZHANG Xiao-dan,HAO Hai-guang,HU Yu,SUN Dong,LI Hong-yan,YANG Jing-xian**(Laboratory of Pharmacology of Traditional Chinese Medicine,Liaoning University of Traditional Chinese Medicine,Dalian 116600,China)  
Objective To investigate the neural preventive function of Duhuo on experimental allergic encephalomyelitis.Methods We used MOG35-55 to induce C57BL/6 mouse EAE model by CNS function test,LFB dyeing and Elisa assay,We detected the immune regulation and neural protection of Duhuo on EAE Multiple sclerosis(MS).Results The high dose of Duhuo could improve the EAE mouse behavior,alleviate neural damage and decrease clinical score obviously,inhibit CNS inflammatory infiltrate and reduce demyelination and decrease IL-17 and IL-23 obviously.Conclusion The results imply that Duhuo has the neural protective function on EAE.
【Fund】: 国家自然科学基金面上项目(81173580);; 辽宁省自然科学基金项(201102144)
【CateGory Index】: R285.5
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