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《Research and Practice on Chinese Medicines》 2013-01
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The Effect of Salvia miltiorrhiza Injection on phenotype Expression of Collagen and Proteoglycan of Chondrocyte

ZHAO zhong1,2,LIU De-chun1,SONG Yang-chun1  
Purpose Chondrocytes in vitro experimental study,to explore the impact of Danshen injection on the cartilage cells to synthesize collagen and proteoglycan.Methods On cartilage cells and passage of culture through on morphology of cultured cells and toluidine blue staining and immunocytochemical identification of articular cartilage cells,select the appropriate passage of chondrocytes,TNF-alpha compare danshen injection after intervention on chondrocytes in vitro expression of type II collagen and proteoglycan change.Results 2.5%,5%,10% Danshen injection can increase the expression of TNF-α-induced articular chondrocytes collagen type II and proteoglycans.Conclusion Danshen injection to promote extracellular matrix synthesis in chondrocytes,reducing the catabolism of chondrocytes,play a protective effect on articular cartilage
【CateGory Index】: R285.5
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