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Anti-tumor Mechanism of Chinese Herbal Compound Shuang-zhu Oil

JIANG Yuan-yuan,YUE Yong-hua,LI Yuan-yuan,LI Xian-rong *(Traditional Chinese Medicine Institute of Shanxi Province,Taiyuan 030012,China)  
Obeject To investigate the anti-tumor mechanism of BELY in vitro and in vivo anti-tumor effect.Method through the use of CCK-8kit to detect K562 and MDA-MB-231,the LOVO and HepG2 cell proliferation;through murine sarcoma S180 and of H22 transplant tumor model to observe the effection of BELY on tumor-bearing mice;Use Elisa to detect of cytokines IL-2,IL-6,IL-12 and TNF-alpha's level to reflect the effect of BELY on immune function of tumor-bearing mice;measured by flow cytometry of tumor-bearing mice peripheral blood T cell subsets of CD4 + and CD8 +,and calculate the ratio of the two types of cells.Results BELY had a certain degree of inhibition on HepG2 and K562,Lovo,MDA231 cells and had the dose-effect relationship.BELY significantly inhibited the growth of the murine sarcoma S180 and of H22,and improve the thymus index,spleen index and weight of the tumor-bearing mice,BELY could be significantly higher serum CD4 + / CD8 + compared with the blank control group(P 0.01 or P 0.05).Conclusion BELY not only directly inhibit tumor cells,but also enhancing immune to achieve the dual proposition of inhibitl tumor.
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