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Study on General Pharmacology of Forskolin and Isoforskolin

ZHAO Ji-kun;YANG Wei-min;YANG Zhi-bing;LI Jia-xun;FU Jian-jian;The Third Affiliated Hospital of Kunming Medical University Kunming;School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products,Kunming Medical University;  
Objective To investigate whether Forskolin(FSK),Isoforskolin(ISOF) has any influences on cardiovascular system and respiratory system of SD rats.Methods(1) 50 SD rats were divided into five groups randomly:Control group(Control),the low(2 mg/kg) and high(6 mg/kg) dose FSK and ISOF group,n = 10 in each group, with the proportion of male and female 1:1. 2) Carotid artery catheters were used for those SD rats, pressure transducer and the multi-channel physiology recorder were applied to record in the heart rate,breathing frequency, systolic blood pressure, mean arterial pressure, diastolic blood pressure. The data were recorded after the monitoring index got stable. Medicines were given from the duodenum after the rats were anesthetized,the heart rate, breathing, systolic blood pressure,mean arterial pressure,diastolic blood pressure were recorded before and 0.5 h, 1 h, 1.5 h, 2 h and 2.5 h after the drug administration in treatment group.Results Compared with before drug administration,the heart rate,breathing rate, systolic blood pressure, mean arterial pressure, diastolic blood pressure of the treatment group had no significant difference 0.5 h, 1 h, 1.5h, 2 h and 2.5 h after drug administration. Compared with control group, the heart rate, breathing, systolic blood pressure,mean arterial pressure,diastolic blood pressure had no significant difference between before and0.5 h,1 h,1.5 h,2 h and 2.5 h after drug administration. Conclusion General pharmacology study shows that the low(2 mg/kg) and high(6 mg/kg) dose of FSK and ISOF has no significant effect on heart rate, breathing,systolic blood pressure,mean arterial pressure,diastolic blood pressure of SD rats.
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