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A comparative morphometrical study on development of upper dental arch in the triosmy 18 with cleft palate mice

WT5”BX]CAI Zhigang, Helmut von Domarus, Eveley Engel Department of Oral and Maxillofacial Surgery, School of Stomatology, Beijing Medical University, Beijing 100081[WT5”HZ]  
Objective [WT5”BZ]The aim of this study was to quantitatively compare the width of the upper dental arch in the whole hard palate and the length of the molar dental arch between the trisomy 18 with cleft palate and euploid without cleft palate mice.[WT5”HZ]Methods [WT5”BZ]With the aid of computer imaging analysis system, we studied 52 pairs in gross morphometric and 30 pairs in histomorphometric, which every pair including one trisomy 18 with cleft palate (Ts+CP) and matched euploid mouse foetuses. The width of the upper dental arch in the whole hard palate (five planes) and the length of the molar dental arch were measured or estimated, furthermore compared quantitatively.[WT5”HZ]Results [WT5”BZ]The width of the whole upper dental arch in Ts+CP foetuses exhibited a “lyrate” arch, which showed a slightly increase in anterior and posterior area of the palatal shelf, but in the premolar region it showed a slightly decrease in cleft specimens.[WT5”HZ]Conclusion [WT5”BZ]Ts+CP foetuses developed significant maxillary retrusion, with an expanded and shortened upper molar dental arch.[WT5”HZ]
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