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《Chinese Science Bulletin》 2014-02
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CpG ODN delivery systems based on nanomaterials

WEI Min;LI Jiang;CHEN Nan;HUANG Qing;FAN ChunHai;Laboratory of Physical Biology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences;  
Artificially synthesized CpG oligodeoxynucleotides(CpG ODNs) can imitate bacterial DNA and effectively stimulate the mammalian immune system in response to signals resulting from hazardous invasion.For this reason,CpG ODNs represent promising materials with a range of applications in the treatment of different infections,allergies and cancers.Unfortunately,however,unmodified CpG ODNs alone can be readily degraded by enzymes,resulting in a reduced level of uptake into cells.Repeated high-dose drug administration is therefore required in these treatments,which largely limits their application.In recent years,significant progress in nanomaterial technology has provided a range of new opportunities for the development of effective delivery systems for nucleotide drugs.Based on reports from the literature,a variety of different nanomaterial-based CpG delivery systems have been developed that show a range of advantages,such as high levels of activity,low toxicity and good biocompatibility,making them excellent candidates for use in therapeutic reagents in immune-related diseases.Herein,we provide an introduction to the background and development history of CpG ODN drugs,including their mechanisms of action and the requirements for successful delivery.Particular emphasis has been given to newly developed CpG delivery systems based on different nanomaterials,with a summary of their respective principles and features.Furthermore,we have provided a sketch of the prospects and future trends expected of these materials.
【Fund】: 国家自然科学基金重大研究计划(90913014)资助
【CateGory Index】: TQ460.1
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