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《Chinese Science Bulletin》 2014-22
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Biosynthesis of poly (3-hydroxypropionate) and its copolymers

YANG Peng;WANG Qi;XIAN Mo;XUE YongChang;ZHAO Guang;CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences;School of Biological Engineering, Dalian Polytechnic University;  
3-Hydroxypropionate is an important platform chemical, and its polymer is a biodegradable plastic with high rigidity and ductility, and exceptional tensile strength. The incorporation of 3-hydroxypropionate in copolyesters can increase in the ductility and biodegradability of the resulting polymers. The biosynthesis of polyesters containing 3-hydroxypropionate requires the addition of precursor molecules that are structurally related to 3-hydroxypropionate, such as acrylate and 1,3-propanediol, because most organisms do not contain this material. The addition of expensive precursors, however, can increase production costs. Two artificial synthetic pathways, including the malonyl-coenzyme A and glycerol pathways, were recently constructed to produce poly(3-hydroxypropionate) from inexpensive carbon sources such as glucose and glycerol. Furthermore, a series of 3-hydroxypropionate-containing copolymers with controllable structures and monomer compositions were recently biosynthesized. Compared with using structurally related precursors, the costs associated with the production of 3-hydroxypropionate-containing polymers have decreased significantly, although these costs are still much higher than those associated with the petrochemical synthesis of plastics. Further research in this area should therefore focus on enhancing the synthetic efficiency of poly(3-hydroxypropionate) and its copolymers, while simultaneously reducing production costs.
【Fund】: 中国科学院“百人计划”(Y310011105)资助
【CateGory Index】: O631.5
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